目的: 了解新冠肺炎疫情暴发前后甘肃省抗菌药用药情况变化。方法: 对比分析疫情暴发前后甘肃省总抗菌药及各类抗菌药的销量、销售金额、用药频度及限定日费用等指标的大小及增减幅度,使用中断时间序列（ITS）对疫情暴发前后抗生素消耗量的变化进行拟合。结果: 与2019年相比,2020年抗菌药总销量和销售金额降幅分别为59.86%和34.11%;疫情暴发后抗菌药的用药频度短期内下降了6550990[β2(95%CI:-12900000~-246845.2),P=0.042];销量降幅前三位的抗菌药类别分别为J01B（140.24%）、J01C（77.05%）和 J01D（70.05%）;肠道内途径用药频度降幅（69.10%）明显高于肠道外途径（25.81%）;基层医疗单位降幅（73.85%）最大,三级医院（47.43%）和二级医院（48.79%）降幅相当;用药频度降幅前三位的药品分别为头孢呋辛（294.13%）、头孢氨苄（212.62%）和阿奇霉素（126.24%）。结论: 疫情暴发后甘肃省抗菌药使用情况短期内有所改善,但整体情况仍不容乐观,未来治理重点应放在基层,加强抗菌药合理使用。
Abstract
Objective: The paper is to understand the changes in antibacterial drug use in Gansu Province before, after the outbreak of COVID-19. Methods: We compared, analyzed the total antibacterial drug, various types of antibacterial drug sales, sales amount, frequency of drug use, DDDc in Gansu Province before, after the outbreak of COVID-19. Interrupted time serieswas used to fit changes in antibiotic consumption before, after the COVID-19outbreak. Results: Compared with2019, the total sales volume, sales amount of antimicrobial drugs in2020decreased by59.86%, 34.11%, respectively. DDDs of antimicrobial drug decreased by6550990in the short term after COVID-19outbreak [β2, P=0.042]. The top three antimicrobial drug categories with decreasing sales volume were J01B, J01C, J01D, respectively. The decrease in the frequency of drug use by enteral routewas significantly higher than that by parenteral route. The greatest decrease was in primary care units, the decrease was comparable in tertiary hospitals, secondary hospitals. The top three specific drugs in terms of decrease in medication frequency were cefuroxime, cefadroxil, azithromycin. Conclusion: The use of antimicrobials in Gansu Province has been improved in the short term following the outbreak of COVID-19, but the overall situation is still not optimistic. Future management should focus on the grassroots level, strengthen the rational use of antimicrobials
关键词
新冠肺炎疫情 /
抗菌药 /
用药情况 /
中断时间序列
Key words
COVID-19 /
antimicrobial drugs /
medication use /
ITS
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