Cost Minimization Analysis of Expanded Hemodialysis Based on Medium Cut-Off Membrane Technology for Treatment of Patients with End-Stage Kidney Disease

doi:10.19546/j.issn.1674-3830.2025.4.013

China Health Insurance ›› 2025, Vol. 0 ›› Issue (4) : 96-103. DOI: 10.19546/j.issn.1674-3830.2025.4.013

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Abstract

Objective: The paper compared the cost-effectiveness of expanded hemodialysis (HDx) enabled by medium cut-off (MCO) membrane technology and hemodiafiltration (HDF) in patients with end-stage kidney disease (ESKD) in China, providing reference for clinical treatment and policy decision-making. Methods: An adverse event decision-tree model was developed from the perspective of the healthcare system, employing the cost minimization analysis to compare costs of HDx and HDF once a week within a one-year time horizon. Sensitivity analysis was performed on key parameters. Results: Within the current pricing regimes in 14 provinces where dialyzers can be charged separately, HDx was associated with an average annual cost saving of 5674.51 yuan per patient compared with HDF when the price of MCO dialyzer was below 278.00 yuan per unit. Medical service fees, MCO dialyzer cost, and hemofilter cost were identified as the most influential factors by sensitivity analysis. Conclusion: HDx may show economic advantages over HDF. These findings will provide valuable pharmacoeconomic evidence for the selection of treatment plans for ESKD patients, and provide a basis for the optimization and efficient allocation of health resources.

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expanded hemodialysis / end-stage kidney disease / medium cut-off membrane / cost minimization analysis

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Cost Minimization Analysis of Expanded Hemodialysis Based on Medium Cut-Off Membrane Technology for Treatment of Patients with End-Stage Kidney Disease[J]. China Health Insurance. 2025, 0(4): 96-103 https://doi.org/10.19546/j.issn.1674-3830.2025.4.013

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