There are policy differences between the place of participation and the place of medical treatment in the settlement of medical treatment in a different place face. In this context, fraudulent activities such as forging information of medical treatment from other places, fabricating medical service projects or falsely reporting medical expenses, and impersonating medical treatment to defraud medical insurance funds occur very often, which are covert, complex, and harms. Through years of practice, the mechanism of the healthcare security system to combat medical insurance fraud and ensure the safety of the fund has become increasingly perfect and has achieved significant results However, there are multiple factors restricting the supervision the medical insurance fraud in the settlement of cross-site medical treatment, mainly reflected in the relatively undeveloped means of medical insurance supervision, the easy breeding of moral hazards in the medical treatment in different regions, weak supervision due to poor cross regional cooperation, and the lack of provincial-level medical insurance coordination, which increase the difficulty of supervision. In order to better ensure the smooth operation of the system and the safety of healthcare security, we should focus on optimizing the regulatory path according to the regulatory status quo and the special situation of cross-site medical treatment, based on the development of China's cross-site medical settlement and summary of characteristics of fraudulent insurance behaviors in settlement for medical treatment in different regions.