Objective: The paper analyzes the practice of exploring the retention of medical insurance fund surplus in the centralized procurement of high-value medical consumables in E Autonomous Prefecture, Hubei Province, in order to provide a reference for the standardized, precise promotion of the retention of medical insurance fund surplus in the centralized procurement of high-value medical consumables. Methods: From the perspective of coordinated regions, the paper takes the centralized procurement of coronary stents as an example, uses descriptive statistical methods to review the practice of exploring the retention of medical insurance fund surplus for centralized procurement of coronary stents in E Autonomous Prefecture, summarizes measures to promote standardized, precise promotion of medical insurance fund surplus retention of high-value medical consumables centralized procurement. Results: The exploration of centralized procurement of high-value medical consumables in E Autonomous Prefecture to retain surplus medical insurance funds complies with national regulations, demonstrates strong operability, achieves good results, which is worth to be promoted