Objective: The application ofin clinical practice is in the stage of popularization, development. The purpose of this study was to explore the comparison of disease category score, medical insurance standard payment of medical insurance inpatients with FFR operation under the DIP policy of Guangzhou2018edition, 2022edition, explore the benefits of medical insurance payment for FFR operation-related diseases, put forward suggestions for disease grouping optimization. Methods: Comparative analysis method was used to analyze, compare the differences in enrollment, standard scores, medical insurance balance of hospitalization data with FFR operation in different versions of DIP disease catalogs. Independent sample T test was used to verify whether there were significant differences in the average medical insurance standard payment under different versions of DIP policies. Using the function statistics method, the total value, average value of the loss data of the diseases with FFR operation in recent three years were summarized, analyzed. Results: Compared with the DIP disease score database of2018edition, the number of diseases with FFR operation in the DIP disease score database of2022edition increased, the standard score payment increased, the payment was more adequate, the loss at the hospital side decreased significantly. Conclusion: DIP disease score database needs further optimization. The2022version of DIP disease database pays more adequate for diseases with FFR operation. The case mix of diseases with FFR operation can be adjusted by applying the operation code as an extended code or a new case mix of diseases to meet the actual clinical needs