Objective: This study aims to investigate the development of neurology based on the reform of DRG payment and provide guidance. Methods: Data on 2022 DRG groups related to neurology in a tertiary general hospital in Guangxi were analyzed with statistical descriptive indicators focusing on efficiency, effectiveness, and benefits. Results: The efficiency and effectiveness indicators were relatively low, with a low disease group coverage rate in specialized disease groups. The relative weight of key disease groups is concentrated in low relative weight disease groups, and the production capacity of medical services in the neurology departments needs to be improved. Conclusions: The reform of the DRG payment method has significantly affected the development of neurology. Through the analysis of DRG data, a refined management could be established, which can improve quality, increase efficiency, and reduce costs. Also, it can improve ability for comprehensive and special therapy, and form the concept of treating patients with difficult or serious illnesses, thereby promoting the high-quality development of neurology.