Objective: The paper analyzes influencing factors of hospital balances under DIP Policy, as to provide theoretical basis and decision-making suggestions for management of medical expenses, cost management of disease groups and health insurance management. Methods: Based on 2022 DIP health insurance payment of cases in a tertiary hospital in Guangdong Province, the paper analyzes factors influencing clinical controllable balances with mean comparison between groups and multiple linear regression. Results: Significant negative correlation was observed between hospital controllable balances and time consumption index as well as cost consumption index of cases. Balances are relatively lower in cases of lower age, of local disease groups, with high positive cost deviation and with level 2 surgery. Balances are relatively higher in cases with level 3 surgery and higher relative weight. Conclusion: Under DIP policy, greater attention should be paid to strategy positioning, resources allocation, operation management and revenue structure. Mechanism of DIP policy needs to be improved continuously to enhance matching between DIP payment and medical resources consumption.