Objective: Taking a tertiary hospital in Jiangxi Province as an example, the paper studies the current situation of outpatient settlement for patients seeking medical treatment across provinces to propose optimization suggestions. Method: We use questionnaire survey and interview methods to collect data and conduct qualitative and quantitative analysis. Also, we select the cross-provincial outpatient settlement data after the official switch to the national healthcare security information platform from December 2021 to December 2022, and perform a second validation on the analysis results. Result: Most patients understand the reimbursement policy for medical expenses across provinces to some extent, especially among long-term residents and retirees resettled in different regions. However, there are still some patients who do not have sufficient understanding of the policy. Conclusion: It is recommended optimizing the policy of cross-provincial settlement, improving the information system, and strengthening the cooperation between designated medical institutions and overall planning areas.