Strengthening the regular supervision of the medical insurance funds use will improve the detection rate of illegal use and defaulting of medical insurance funds, but this paper believes that its specific goal should be effectively deter the illegal behaviors and defaulting above with less supervision and law enforcement costs, so as to maximize the law-abiding and compliance with the limited law enforcement resources. At this stage, China's medical insurance fund supervision still has problems such as limited law enforcement resources and supervision capacity. This paper elaborates on the connotation and specific goals of regular supervision of the use of medical insurance funds, and believes that the following three paths can be used to achieve the goals above, i.e. strengthening and improving intelligent supervision of medical insurance funds, innovating, optimizing, and comprehensively using various regulatory methods, strengthening self-management of designated medical institutions and pharmacies, and innovating systems such as no penalty in case of compliance.