With the deepening of China's medical reform, the mechanism of "supporting medicine with drugs" has been broken down, and the amount of prescriptions dispensing outside the hospital has been increasing year by year. The number of patient complaints caused by prescriptions dispensing outside also increased significantly. This article conducts an in-depth analysis of the problems of frequent violations, regulatory difficulties and disputes in prescriptions dispensing outside, and proposes countermeasures and suggestions such as building an information platform for prescriptions dispensing outside, implementing unified medical insurance payment policies, strengthening standardized management of prescription dispensing outside, promoting establishment of the standardized development of chain retail pharmacies, exploring cooperation between medical and pharmaceutical institutions, and constructing a unified pharmacist management system.