In order to promote the implementation of national negotiated drug policies, the Nanjing Healthcare Security Administration and Health Commission jointly released The Implementation Plan for Establishing and Improving the “Dual Channel” Management Mechanism for National Medical Insurance Negotiated Drugs (Ningyifa〔2021〕No.70), which meets clinical and patients' medication needs through two channels of designated medical institutions and designated retail pharmacies. Since the implementation of the policy, the Healthcare Security Administration has been the decision-maker and executor of the policy, medical institutions have been the primary responsible body for the allocation and use of national negotiated drugs, and designated retail pharmacies have been an important body for the supplementary guarantee of national negotiated drug supply, jointly ensuring the implementation of the "dual channel" of national negotiated drugs. However, there are also some urgent problems to be solved, such as the vague definition of the scope of drugs included in the "dual channel" management, the inadequate implementation of supporting policies, the failure to establish a dynamic management mechanism for designated retail pharmacies, the blocked direct settlement for medical treatment in different places, and the insufficient supply of drugs for rare diseases. Therefore, the relevant authorities should coordinate with each other to promote the smooth implementation of the "dual channel" of the national negotiated drug, such as clearly defining the scope of drugs included in the "dual channel" management, improving the motivation of hospitals to supply "dual channel" drugs, establishing a "dual channel" dynamic management mechanism for designated retail pharmacies, facilitating the direct settlement of off-site medical treatment, and improving the supply guarantee level of rare disease drugs.