Objective: The prevalence of hypertension in China is increasing rapidly, and the calculation of its disease burden is helpful for the government to reasonably plan the health resources, improve the medical security system, and effectively reduce the expenditure of hypertension on individuals, families and society. Methods: Stata16.0 was applied to clean and filter the data, Spss21.0 was used to analyze the data, and two-step model method and human capital approach was used to calculate the direct and indirect economic burden of hypertension in Shenzhen in 2018. Results: The economic burden of hypertension in Shenzhen in 2018 was 3.1225 billion yuan, of which the direct economic burden was 2.8605 billion yuan and the indirect economic burden was 262 million, accounting for 0.18% of the GDP of Shenzhen. Conclusion: The economic burden of hypertension in Shenzhen is relatively heavy, showing an upward trend. The economic burden of outpatient service is higher than that of inpatient service, and the drug cost accounts for a relatively high proportion. The construction of community chronic disease prevention and control network should be strengthened, the supervision system of medical insurance should be improved, and the internal management of hospitals should be strengthened.