Diagnosis-Intervention Packet (DIP) is an innovative application in the field of medical insurance payment reform based on general equilibrium and principles of big data. As the DIP reform enters the stage of actual payment, it is worth studying what measures public hospitals should take to deal with the uncertainty brought about by the reform and obtain reasonable medical insurance payment. This study carried out analysis of hospital's coping strategies after the implementation of DIP in a public hospital in Hainan Province through questionnaires and other methods. The study found that the public hospital effectively increased the grouping rate of diseases and obtained reasonable medical insurance funds by means of clinical pathway management, the first page of medical record quality control, and single-disease payment standard management. The research results show that under the reform of medical insurance payment methods, medical institutions should consolidate the foundation of informatization through standardizing the quality control of medical records, clinical path management and single disease cost management. Meanwhile, they should develop advantageous disciplines according to functional positioning, adapt to changes and steadily promote high-quality development of hospitals.