Objective: The paper summarizes and analyzes the policy implementation for ambulatory chemotherapy payment methods in various regions in China, explores the current situation and problem of medical insurance payment to provide support for payment policy of ambulatory chemotherapy. Methods: Using ambulatory chemotherapy, day services as key words, we search the local human resources and social security departments, healthcare security departments. The relevant policy documents released from January 2013 to January 2023 were selected and summarized. On this basis, the future development direction of medical insurance management of ambulatory chemotherapy from the perspective of medical insurance, medical institutions and patients were discussed. Results: There are only a few regions that have issued medical insurance management policies for ambulatory chemotherapy. Ambulatory chemotherapy is usually included in the scope of medical insurance payment as inpatient medical services. In most regions, ambulatory chemotherapy is included in the management of single disease or DRG/DIP payment. Conclusion: Ambulatory chemotherapy conforms to the direction of the national medical reform. All regions should improve the payment method of medical insurance for ambulatory chemotherapy under the premise of standardized management.