Objective: The paper studies the situation of inpatient medical services based on DRG indicators in specialized rehabilitation institutions, and provides a reference for refined hospital management and medical insurance payment reform. Methods: All inpatient cases paid by DRG from a tertiary hospital in Guangxi from 2021 to 2022 were selected as the research subjects. The number of DRG groups, total relative weight (RW) of DRG, CMI, time consumption index, and cost consumption index were calculated, and the changes and influencing factors of DRG indicators in specialized rehabilitation institutions in different years were analyzed. Results: Compared with 2021, the number of DRG groups increased by 40.18%, the number of cases whose RW was greater than or equal to 2 decreased by 88.65%, the CMI decreased by 5.29%, the time consumption index decreased by 6.80%, and the cost consumption index increased by 31.76% in 2022. Compared with the period before the DRG reform (2020), the average length of stay decreased by 38.96%, and the average cost per visit decreased by 24.51% in 2022. Conclusion: Under the DRG payment, specialized rehabilitation hospitals apply the comprehensive hospitals' reform model, with the same grouping rules and weight scheme. The efficiency of medical services is improving year by year, but the change in medical service capacity is not significant. The specialized rehabilitation hospitals achieve results under the DRG payment reform, but DRG payment is not fully suits them. It is recommended to fully consider the characteristics of specialized rehabilitation hospitals, optimize grouping rules and weight schemes, and explore suitable payment models and medical service capacity evaluation systems for specialized rehabilitation hospitals.