Taking Shandong Province as an example, this paper studies the national, provincial drug negotiations from2016to2019, analyzes the drug purchase volume, purchase amount, delivery time as well as drug availability, finds that drug negotiation has improved the drug purchase volume, purchase amount of public medical institutions, retail pharmacies. Drug prices after the negotiation dropped significantly, under the dual influence of the increase in purchase volume, the decline in prices, the availability of drugs has been improved. It is recommended to continue to promote the construction of a "dual-channel" management mechanism for designated medical institutions, retail pharmacies to further improve the availability of negotiated drugs