Objective: We aim to investigate the accessibility of antitumor drugs in the special drug catalogue of Shaanxi Province in designated medical institutions. Methods: We selected31antitumor drugs in the special drug list of Shaanxi Province from2019to2021, evaluated the accessibility of antitumor drugs by core indicators such as availability, utilization of drugs. Results: From2019to2021, the average annual availability of antitumor drugs in designated medical institutions was1.4% to36.5%. The highest availability occurred in Xi'an, which was significantly higher than that of other regions in Shaanxi Province. The average annual availability of national negotiation drugs was significantly higher than that of conventional Class B drugs, the average annual availability of injectable drugs was significantly higher than that of oral drugs. The total purchase amount of31antitumor drugs increased from263million Chinese yuanin2019to CNY683million in2021. The highest average annual growth rate of procurement costs occurred in Xi'an, accounting for64.0% of total annual procurement in Shaanxi Province. Conclusions: The availability, purchase amount, DDDs of antitumor drugs in designate medical institutions in the special drug catalogue of Shaanxi Province increased annually, the overall accessibility needs to be further improved