Objective: The paper provides ideas for the design of price formula for centralized procurement of drugs with quantity using comprehensive scoring method. Methods: We summarize the use of price formulas in local drug centralized procurement practice, clarify the connotation of different price formulas, interpret the characteristics, risks of different formulas from five dimensions. Results: At present, the commonly used price formulas can be summarized into five categories, different formulas can meet different policy objectives. Conclusion: The choice of price formula should suit the actual work, make the formula simple, clear, reasonably select the value, quantity of relative number, pay attention to the risk of price weight degradation, etc., strive to scientifically, comprehensively transform the price factors into price scores