Objective: The paper studies the application of nursing intervention based on responsibility system in pelvic inflammation and its impact on hospitalization expenses. Methods: A total of 52 patients with pelvic inflammatory disease admitted to Ganbei Hospital from April 2020 to April 2022 were selected as the research objects, and were randomly divided into the control group and the experimental group, with 26 patients in each group. The control group was given routine nursing intervention, and the experimental group chose responsibility system nursing intervention on the basis of the control group. Results: The study showed that the total score of quality of life in the experimental group was significantly higher than that in the control group (P﹤0.05). The total treatment compliance of the experimental group was 96.15%, higher than 76.92% of the control group, and the hospitalization cost of the experimental group was lower than that of the control group, which was statistically significant (P﹤0.05). Conclusion: Nursing intervention based on the responsibility system is conducive to improving the quality of life of patients, increasing treatment compliance, reducing hospitalization costs, and reducing the economic burden of patients.