Objective: The paper analyzes the influence of coronary stent national centralized procurement on disease groups of percutaneous coronary intervention. Methods: According to the first page of percutaneous coronary intervention in four hospitals, the changes of disease cost, average hospitalization days and surgical operation before and after coronary stent centralized procurement were analyzed. Results: The average hospitalization days decreased by 12.26%, the average cost of hospitalization decreased by 29.69%, the cost of materials decreased by 44.47%, the cost of drugs, examination and inspection also decreased, and the cost of medical services increased. The proportion of coronary stent implantation decreased significantly from 86.24% to 78.61% (P﹤0.05), the ratio of stent implantation decreased from 93.32% to 84.35% (P﹤0.05), and the ratio of ordinary balloon operation increased from 82.95% to 87.45% (P﹤0.05). The ratio of drug balloon operation increased slightly, but there was no significant difference. Conclusion: After coronary stent procurement, the cost of percutaneous coronary intervention has decreased significantly, and there are differences in the cost structure and operation methods among different hospitals. It is recommended that hospitals continuously optimize the cost structure of diseases under the background of DRG payment, so as to promote the healthy development of hospitals.