Objective: The paper explores the effect of standardized comprehensive nursing on medical costs of patients with Caesarean section. Methods: 50 patients who underwent c-section in hospital from October 2019 to January 2022 were selected as subjects and divided into the control group (n=25) and the observation group (n=25) by random number table method. The control group was given routine nursing,and the observation group was given standardized comprehensive nursing on the basis of routine nursing. The effect of the two groups was evaluated,and the clinical recovery, quality of life, medical costs and postpartum complications of the two groups was compared. Results: The hospitalization time, gastrointestinal function recovery time, lactation time, pain intensity and medical expenses of the observation group was lower than those of the control group (P﹤0.05). The score of quality of life in the observation group was higher than that in the control group (P﹤0.05), and the incidence of postpartum complications in the observation group was lower than that in the control group (P﹤0.05). Conclusion: Standardized comprehensive nursing can improve the physical and mental health of patients with Caesarean section, reduce medical costs, save medical insurance funds and help to reduce maternal economic burden, thus it is worthy of promotion.