With the normalization of the national centralized drug procurement, some of the first four batches of drugs have expired, and follow-up procurement of the first and the third batch have been carried out. This paper attempts to analyze the first and third batch of follow-up mode, refine and analyze the follow-up modes of different regions and alliances, analyze the effects of the first and third batches in some regions and the changes in the follow-up environment and policy requirements of the second and fourth batches, and put forward policy suggestions for the optimization of follow-up rules.