The centralized procurement of in-vitro diagnostic reagents is an important part of the strategic purchase and centralized medical procurement management in the field of medical reform in China. At present, various procurement work modes have both advantages and disadvantages and need to be improved. This paper introduces, compares and analyzes four current main procurement work modes, including hospital-level independent non-centralized procurement, prefectural-level centralized bidding procurement, provincial-level centralized online procurement, and provincial-level centralized procurement with volume, and puts forward policy suggestions.