In order to further enhance the level of specialization and standardization in the regulation of health insurance funds, Jiangxi Province has taken the lead in setting up provincial-level health insurance monitoring centers throughout the country, and has vigorously promoted the construction of municipal-level health insurance monitoring institutions, thus full coverage of medical security monitoring institutions at provincial and municipal levels has been achieved. This paper summarizes the main methods of promoting the establishment of healthcare security monitoring institutions from the aspects of team-building, empowerment, accountability, working system and working mechanism construction, analyzes the effect, and puts forward suggestions to provide reference for the establishment of health insurance fund supervision administration, the strengthening of fund supervision team, and the formation of long-term mechanism of fund supervision.