Objective: The paper is to evaluate the impact of clinical pathways on DRG indicators, and provide reference for medical institutions to actively adapt to the reform of medical insurance payment methods. Methods: Based on the data of the DRG evaluation index system before and after clinical pathway management, the patients in a tertiary hospital in Sichuan Province from January 2019 to July 2021 are used as the research object, and the interrupted time series model is applied to evaluate the policy impact and trend changes before and after the intervention. Results: After the intervention, the CMI value and total weight increased by 0.001 and 31.197 respectively, and the time consumption index and cost consumption index decreased by 0.004 and 0.006 each month. The standardized mortality rate decreased by 0.068 per month. Conclusion: The clinical pathway has the greatest impact on efficiency indicators, and changes in productivity indicators and safety indicators are not obvious.