Objective: The paper attempts to explore the awareness and satisfaction of patients in Peixian County on the centralized drug procurement, depending on whether its implementation can reduce the economic pressure of patients.Methods: 1350 outpatients in Peixian County, Jiangsu Province from January 2020 to August 2020 were selected as the research objects. Questionnaires were distributed to collect data. The patients' awareness and satisfaction with the policy was analyzed by univariate analysis and multivariate binary logistic regression analysis.Results: The results of univariate analysis showed that age, income, place of residence, educational background, working status and medical background were the influencing factors of patients' cognition of the policy. The results of multivariate analysis showed that income, educational background and medical background were the independent influencing factors of patients' awareness of the policy. The results of univariate analysis showed that age, medical background and policy cognition were the influencing factors of patients' satisfaction with the policy. The results of multivariate analysis showed that medical background and policy cognition were the independent influencing factors of patients' satisfaction with the policy.Conclusion: Strengthening publicity and improving patients' awareness and satisfaction with the policy is conducive to expanding the scope of application and benign impact of the policy.