Although the application of Health Technology Assessment (HTA) in the field of medical insurance decision-making in China is in an initial stage, there will be plenty of room for application in the future due to the high consistency between the discipline characteristics and the needs of medical insurance decision-making. China's medical insurance management system can not blindly copy foreign models. We need to explore a road of medical insurance HTA application with Chinese characteristics in practice. The long-term sustainable development of HTA in medical insurance is inseparable from the long-term contribution of government in the construction of mechanism. The medical insurance administration can actively explore the system construction of HTA in reform tasks such as the adjustment of the national medical insurance drug catalogue, and gradually form the development model of medical insurance HTA in China. The paper introduces the roles, concepts and international experience of HTA, and elaborates application of HTA in healthcare security decision-making in China accordingly.