Since the implementation of centralized drug procurement organized by the state, the calculation of surplus funds has a very important incentive effect on medical institutions. Combined with the actual work of Anhui Province, this paper simulates and calculates the relevant parameters and indicators, classifies and analyzes the different reported volume of various medical institutions, and finally obtains some suggestions. When reporting the volume, medical institutions can appropriately float up the agreed purchase volume base, and guide patients to minimize the use of non winning products or non winning drugs whose purchase price is lower than the winning price, so as to maximize the remaining funds of various varieties..