Data Center is an important part of the National Healthcare Security Information System. It undertakes the tasks of storage, calculation, governance and application of medical insurance big data. In June 2019, the National Healthcare Security Bureau formulated The Guidelines for the Construction of Healthcare Security Information Platform, and all localities carried out the construction of data platforms according to the standards of the guidelines. With the completion and launch of the healthcare security information system, the construction of medical insurance data centers around the country has basically achieved the objectives set in The Guide. However, the diversity of local actual construction also puts forward higher requirements for the further use and follow-up development of data center. Combined with the construction goal of data center, this paper interprets The Guide from the perspective of architecture, summarizes practical experience and puts forward some thoughts on the construction of data center.