Objective: The paper is to understand the changes in antibacterial drug use in Gansu Province before, after the outbreak of COVID-19. Methods: We compared, analyzed the total antibacterial drug, various types of antibacterial drug sales, sales amount, frequency of drug use, DDDc in Gansu Province before, after the outbreak of COVID-19. Interrupted time serieswas used to fit changes in antibiotic consumption before, after the COVID-19outbreak. Results: Compared with2019, the total sales volume, sales amount of antimicrobial drugs in2020decreased by59.86%, 34.11%, respectively. DDDs of antimicrobial drug decreased by6550990in the short term after COVID-19outbreak [β2, P=0.042]. The top three antimicrobial drug categories with decreasing sales volume were J01B, J01C, J01D, respectively. The decrease in the frequency of drug use by enteral routewas significantly higher than that by parenteral route. The greatest decrease was in primary care units, the decrease was comparable in tertiary hospitals, secondary hospitals. The top three specific drugs in terms of decrease in medication frequency were cefuroxime, cefadroxil, azithromycin. Conclusion: The use of antimicrobials in Gansu Province has been improved in the short term following the outbreak of COVID-19, but the overall situation is still not optimistic. Future management should focus on the grassroots level, strengthen the rational use of antimicrobials
Key words
COVID-19 /
antimicrobial drugs /
medication use /
ITS
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