Objective: The paper analyzes the impact of medical insurance payment reform on the average medical expenses, satisfaction of neurosurgery inpatients. Methods: We selected80inpatients in neurosurgery department of a hospital in Wuxue City as the object of study.40patients paid by traditional medical insurance from June2020to June2021was listed as the control group, while40patients paid by DIP from July2021to June2022were listed as the observation group. The average medical cost, satisfaction of the two groups were compared. Results: The average examination cost, average drug cost, average operation cost, average hospitalization cost, other cost of the observation group were lower than those of the control group, the satisfaction rate of diagnosis, treatment was higher than that of the control group. Conclusion: Promoting the reform of DIP medical insurance payment is of positive significance for controlling patients' medical costs, improving patients' satisfaction rate of diagnosis, treatment, reducing doctor-patient disputes, improving the overall service quality of the hospital