Objective: The paper explores the influence of clinical pathway reform on medical expenses, individual burden of medical insurance inpatients. Methods: Cerebral infarction, cerebral hemorrhage, transient ischemic attack, chronic obstructive pulmonary disease were selected as clinical pathway implementation diseases in a Class A hospital in Shandong Province. Relevant data of medical insurance inpatients from2019to2021were analyzed, interrupted time series analysiswas used to analyze the effects of clinical pathway reform on average inpatient cost per time, drug proportion, patient self-expense. Results: After the implementation of clinical pathway reform, the average hospitalization cost per time, drug proportion of patients showed a downward trend. The self expenses increased first, then decreased. Conclusion: The implementation of clinical pathway reform has a positive effect on controlling the unreasonable growth of medical cost