Objective: The paper evaluates the implementation effect of centralized procurement of psychotropic drugs to provide reference for promoting, improving centralized procurement of psychotropic drugs. Methods: The use of selected drugs of a psychiatric hospital from December2019to August2022were collected, compared, analyzed, including the number of selected products, the amount of use, the sales amount, the agreed task amount, average cost per time of selected key varieties of psychiatric category, the amount of prescriptions, DDDs, the average drug cost per outpatient/inpatient, adverse drug reactions, other indicators. Results: The tasks of each batch of centralized purchase were overfulfilled, the sales volume of centralized purchase varieties increased significantly, with the highest increase of1269.71%. Compared with the same period of the previous year, the total sales amount of non-selected drugs with the same generic name decreased significantly, with a maximum decrease of254.19%. The maximum ratio of prescription quantity of selected varieties/non-selected varieties was30.88. The average drug cost per outpatient/inpatient decreased gradually. The average drug cost of the selected varieties of psychiatric products decreased significantly compared with that before centralized purchase, with the maximum decrease of84.07%. Conclusion: The centralized purchase of psychotropic drugs reduces the drug costs for patients with mental diseases, improves the efficiency of medical insurance funds