Objective: The paper analyzes the influence of DIP on the therapeutic effect of patients in the endocrinology department. Methods: 120patients from the endocrinology department of People's Hospital in a county from May2020to May2021were selected as the fee-for-service group, 68patients from June2021to May2022were selected as the DIP group. The hospitalization expenses, reimbursement amount of medical insurance, self-expense amount, satisfaction, treatment effect of the two groups were compared, analyzed. The examination, treatment, other items of the fee-for-service group shall be settled uniformly after discharge. The DIP group will be paid according to the disease type. Results: The inpatient expenses, the amount of self payment in the DIP group were lower than those in the fee-for-service group （P<0.05）, the satisfaction was higher than that in the fee-for-service group （P<0.05）. The total effective rate of98.53% in the DIP group was higher than that of89.17% in the fee-for-service group （P<0.05）. Conclusion: The DIP can reduce hospitalization expenses, the amount of self payment, improve the efficiency of medical insurance fund, make the hospital obtain higher patient satisfaction, better treatment effects