Objective: With the promotion of the national medical security policy of direct settlement of transprovincial medical treatment, the paper puts forward suggestions for improving the policy through the analysis of the inpatient medical expenses, treatment situation of transprovincial patients. Methods: In this paper, the inpatient expenses of ecdemic patients in a first-class hospital in Jiangsu Province were analyzed, SPSS24.0was used to explore the influence of the patient's age, gender, length of stay, cost structure, other factors on the inpatient expenses. Results: Compared with medical insurance patients with other identities, the hospitalization resource consumption of medical insurance patients in different places was larger due to the differences in age, length of stay, characteristics of diseases. Conclusion: It is suggested to further enhance the level of medical insurance pooling, improve mutual aid ability. We will continue to explore the principle of the same price for the same disease, improve the system's universality. Also, we should build a unified national medical insurance information intelligent audit platform, promote the fine management of hospital medical insurance funds