Objective: The paper analyzes the implementation status of "dual channel" management of national negotiated drugs in S Province, analyzes the factors affecting the availability, so as to provide reference for governments to improve relevant policies, the availability of drugs for patients. Methods: The data were collected from the S Province State-negotiated Drug Monitoring Platform, the official policy documents, reports were investigated, the availability analysis was conducted using Excel, WHO/HAI standard survey method. Results: The "dual channel" management of state-negotiated drugs in S Province achieved initial results, the overall availability of drugs was improving, but there were differences among institutions, diseases, the availability of specific varieties was generally low. The factors affecting accessibility included policy coordination, medical institution diagnosis, treatment level, information system construction. Conclusions: It is suggested to improve the construction of medical institutions, coordinate regional development, establish communication, coordination mechanism, strengthen supervision, management, establish an accessibility index system, carry out systematic evaluation on a regular basis, strengthen policy publicity, education