Objective: The paper explores the preventive effect of home-based nursing intervention in chronic hepatitis B and its impact on hospitalization expenses. Methods: 92 patients with chronic hepatitis B from March 2020 to may 2021 were selected as the subjects of this study. They were randomly divided into two groups, with 46 cases in each group. The control group was treated with routine nursing, and the research group was combined with family-based nursing intervention. After 4 weeks of nursing, the self-management level, hospitalization expenses, satisfaction and compliance of patients were observed and summarized. Results: The scores of lifestyle, medication compliance, self-examination and consultation consciousness in the research group were higher than those in the control group (P<0.05). The scores of satisfaction and compliance, and hospitalization expenses were also higher than those of the control group (P<0.05). Conclusion: Family-based nursing intervention has many advantages for patients with chronic hepatitis B, which is conducive to improving clinical performance, improving self-management level, and reducing the hospitalization cost. It is worth popularizing and applying.