Healthcare security fund is the people's medical treatment money and life-saving money. Its use safety is related to the vital interests of the masses and the healthy and sustainable development of the healthcare security system. Taking the construction of healthcare security fund supervision credit system in Nanning as an example, this paper summarizes its construction experience, main highlights and achievements, and puts forward innovative and optimization strategies to explore healthcare security fund supervision. Practice shows that the fund supervision system based on healthcare security credit management established in Nanning and the healthcare security fund supervision platform of 1 middle platform plus 4 system have realized the operation mechanism led by the healthcare security department, mutual supervision and self-conscious standardization. In practice, an innovative healthcare security fund supervision mode based on credit management has been formed, which provides a useful reference for promoting the development of the industry.