目的: 评价抗菌药物集采对妇产科和小儿骨科围手术期预防用药的影响,为推进和完善抗菌药物药品集中采购提供参考。方法: 以临沂市某三甲医院为例,采用回顾性方法收集第五批国家药品集中采购中选药品（注射用头孢呋辛钠）集采前半年（2021年1月1日至2021年6月30日）和集采后半年（2022年1月1日至2022年6月30日）药品消耗量、销售金额、用药频度（DDDs）、日均费用（DDDc）、可负担性等数据,并进行对比分析。结果: 集采政策实施后,妇产科平均住院日由6.98天降至6.21天,降幅为14.29%,例均药品费用、例均药占比、头孢呋辛钠例均费用、DDDc分别降幅30.70%、19.26%、7.5%和12.43%;小儿骨科平均住院日由9.76天降至8.50天,降幅为12.91%,头孢呋辛钠例均费用、DDDc降幅分别为1.17%和13.69%。结论: 集采政策的有效实施降低了注射用头孢呋辛钠的价格,提高了患者的可负担性、医保基金的使用效率,降低了医院运营成本。

Objective: The paper evaluates the impact of centralized procurement policies for antibiotics on perioperative prophylactic medication in obstetrics, gynecology, and pediatric orthopedics, providing reference for promoting and improving centralized procurement of antibiotics. Methods: Taking a tertiary hospital in Linyi City as an example, a retrospective method was used to collect data on drug consumption, sales amount, medication frequency (DDDs), daily cost (DDDc), and affordability for the first half of the year (January 1, 2021 to June 30, 2021) and the second half of the year (January 1, 2022 to June 30, 2022) of cefuroxime sodium for injection, which was selected in the fifth batch of national drug centralized procurement, for comparative analysis. Results: After the implementation of the centralized procurement policy, the average length of hospital stay in obstetrics and gynecology decreased from 6.98 days to 6.21 days, with a decrease of 14.29%. The average cost of drugs per case, the proportion of drugs cost per case, the average cost of cefuroxime per case, and DDDc decreased by 30.70%, 19.26%, 7.5%, and 12.43%, respectively. The average length of hospital stay in pediatric orthopedics decreased from 9.76 days to 8.50 days, with a decrease of 12.91%. The average cost per case and DDDc of cefuroxime decreased by 1.17% and 13.69%, respectively. Conclusion: The implementation of the national centralized drug procurement policy effectively lowered the price of cefuroxime sodium for injection, improved patient affordability, increased the efficiency of medical insurance funds and reduced operating costs of hospitals.